Insulators: many functions, many mechanisms.
نویسندگان
چکیده
منابع مشابه
Chromatin insulators: regulatory mechanisms and epigenetic inheritance.
Enhancer-blocking insulators are DNA elements that disrupt the communication between a regulatory sequence, such as an enhancer or a silencer, and a promoter. Insulators participate in both transcriptional regulation and global nuclear organization, two features of chromatin that are thought to be maintained from one generation to the next through epigenetic mechanisms. Furthermore, there are m...
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With advances in genetic science, the dynamic structure of eukaryotic genome is considered as basis of gene expression regulation. Long-distance communication between regulatory elements and target promoters is critical and the mechanisms responsible for this connection are just starting to emerge. Chromatin insulators are key determinants of proper gene regulation and precise organization of c...
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Chromatin insulators are DNA-protein complexes with broad functions in nuclear biology. Drosophila has at least five different types of insulators; recent results suggest that these different insulators share some components that may allow them to function through common mechanisms. Data from genome-wide localization studies of insulator proteins indicate a possible functional specialization, w...
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Flashover of polluted insulators in contaminated areas is one of the most important factors influencing the operation of transmission and distribution lines and finally line outages. Therefore, it is essential to prevent and detect flashover in the insulators. Hence, utilizing the insulator status monitoring systems and predicting their functions have absorbed a lot of attention over the recent...
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عنوان ژورنال:
- Genes & development
دوره 16 3 شماره
صفحات -
تاریخ انتشار 2002